Study Information
Summary of a study to compare the effects of two toothpastes on isolated and biofilms bacteria.
Dr. J-P Perraudin and Dr. P Courtois, Université Libre de Bruxelles. Journ. Int. Acad. Pério. 2001 : 120 (Abstract).
Two different aspects of the microflora colonisation can be distinguished.
The first consists of an isolatedform observed mainly in saliva.The second consists of a colonised form which can be observed in dental plaque or on mucosal surfaces.
The use of antimicrobial agents for the prevention and treatment of periodontal and dental plaque-related diseases is attracting con-siderable interest within the dental profession.
The present study compares the effectiveness in vivo of two tooth¬paste formulations : Toothpaste A - containing the LactoperoxidaseSystem producing OSCN- (hypo- thiocyanite), and a Toothpaste B - containing Lactoferrin, Lysozyme,Lactoperoxidase System and Colo- strum Extract as antimicrobial agents.
Results indicate Toothpaste A has an inhibitory effect on a limited number of the planktonic bacteria present in the patients’ saliva. Conversely, Toothpaste B, containing a mixture of antibacterial agents in conjunction with Immunoglobulinsand Growth Factors (purified from Colostrum) was shown to be instrumental in removing colonised (biofilm) bacteria and to have a greater effect in controlling the subsequent higher proportion of planktonic bacteria found in the saliva.
The antibacterial activity for both formulations was calculated by an ATP assessment of the bacteria versus the number of bacteria present.
Removal of the biofilm bacteria was demonstrated by observing the number of planktonic bacteriain the saliva of the patients using Toothpaste B compared to the number of bacteria in the saliva of the patients using Toothpaste A.
The action of Toothpaste B on the biofilm bacteria was also characterised by a reduction in dental plaque and lactic acid production.
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